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Sulfide analogues as potent and selective M(2) muscarinic receptor antagonists
Yuguang Wang1, Samuel Chackalamannil, Zhiyong Hu
1Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. yuguang.wang@spcorp.com
Bioorganic & Medicinal Chemistry Letters
|March 23, 2002
Abstract:
We have discovered highly potent, selective sulfide M(2) receptor antagonists with low molecular weight and different structural features compared with our phase I clinical candidate Sch 211803. Analogue 30 showed superior M(2) receptor selectivity profile over Sch 211803. More importantly, this study provided new leads for the discovery of M(2) receptor antagonists as potential drug candidates.