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Modification of some hematologic and biochemical indices in mice consecutive mecadox administration
Abstract:
Mecadox addition to the diet of laboratory mice in doses of 25 mg/kg/day for 30 days resulted in some hematologic and biochemical modifications: 1. Red cell count declined moderately, leucocyte and neutrophile count was higher and reached their normal values 15 days following treatment. 2. Modifications of liver transaminases expressed by a diminution of GOT and GPT activities were observed together with a reduction of free nitrogen. Values returned to normal within 15 days after treatment. 3. Mecadox stimulated weight gain in treated animals during the first 15 days of treatment. No significant differences were observed in weight gain between the two groups during the period which followed treatment.
Insights
Mecadox (carbadox) in mice diets moderately affected blood cell counts and liver enzymes, with values normalizing post-treatment. It also initially stimulated weight gain in laboratory animals.
Area of Science:
- Veterinary Pharmacology
- Toxicology
- Animal Science
Background:
- Mecadox (carbadox) is an antimicrobial feed additive used in livestock.
- Understanding its physiological effects in laboratory animals is crucial for safety assessment.
Purpose of the Study:
- To investigate the hematologic and biochemical effects of Mecadox in laboratory mice.
- To assess the impact of Mecadox on animal weight gain and recovery.
Main Methods:
- Laboratory mice were administered Mecadox at 25 mg/kg/day for 30 days.
- Hematologic parameters (red cell count, leukocyte, neutrophil) and liver enzymes (GOT, GPT) were monitored.
- Weight gain was measured throughout the treatment and recovery periods.
Main Results:
- A moderate decline in red blood cell count was observed, alongside elevated leukocyte and neutrophil counts, which normalized 15 days post-treatment.
- Decreased GOT and GPT activities and reduced free nitrogen levels were noted, with normalization within 15 days after treatment cessation.
- Mecadox stimulated weight gain during the initial 15 days of treatment, with no significant long-term differences observed.
Conclusions:
- Mecadox administration induces transient hematologic and biochemical changes in mice.
- The observed effects are reversible, with physiological parameters returning to normal levels after treatment withdrawal.
- Mecadox demonstrates a short-term growth-promoting effect in laboratory mice.