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Viper venom components affecting angiogenesis.

T F Huang1, C H Yeh, W B Wu

  • 1Pharmacological Institute, College of Medicine, National Taiwan University, No. 1 Jen-Ai Road, Sec. 1, Taipei, Taiwan, ROC. turfu@ccms.ntu.edu.tw

Haemostasis
|March 23, 2002
PubMed
Summary

Rhodostomin, a disintegrin, effectively inhibits angiogenesis by blocking endothelial cell functions and tumor neovascularization. This compound suppressed tumor growth and improved survival in mice, highlighting its potential as an anti-cancer therapeutic.

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Area of Science:

  • Molecular Biology
  • Cell Biology
  • Oncology

Background:

  • Angiogenesis, the formation of new blood vessels, is crucial for solid tumor progression.
  • Disintegrins and glycoprotein-IIb/IIIa-binding proteins are investigated for their anti-angiogenic properties.

Purpose of the Study:

  • To evaluate the effects of disintegrins, specifically rhodostomin and accutin, on endothelial cell functions and angiogenesis.
  • To assess the in vitro and in vivo anti-angiogenic and anti-tumor efficacy of rhodostomin.

Main Methods:

  • In vitro assays using human umbilical vein endothelial cells (HUVECs) to assess viability, capillary tube formation, migration, and invasion.
  • In vivo studies using the chick chorioallantoic membrane model and B16F10 melanoma tumor models in mice.
  • Evaluation of neovascularization, tumor growth, and animal survival.

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Main Results:

  • Rhodostomin inhibited HUVEC viability, capillary tube formation, migration, and invasion induced by basic fibroblast growth factor (bFGF).
  • In vivo, rhodostomin suppressed bFGF- and B16F10 melanoma cell-induced angiogenesis, reduced tumor growth, and prolonged mouse survival.
  • Agkistin did not exhibit significant anti-angiogenic effects.

Conclusions:

  • Rhodostomin demonstrates potent anti-angiogenic and anti-tumor activities.
  • Its mechanism may involve blocking the interaction between endothelial αvβ3 integrin and extracellular matrix.
  • Rhodostomin shows promise as a therapeutic agent for inhibiting tumor angiogenesis and growth.