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Updated: Oct 2, 2026

Modeling Posthemorrhagic Hydrocephalus of Prematurity in Rats
Published on: March 28, 2025
[Re-emergence of hemorrhagic disease in newborns. Implications for its prevention]
Oscar Alberto Newton-Sánchez1, Gloria Basurto-Celaya, Vesta Richardson
1Servicio de Enseñanza e Investigación, Hospital del Niño Morelense, Gustavo Gómez Azcárate 205, Lomas de la Selva, 62270 Cuernavaca, Morelos, México.
Objective:
To describe the occurrence of hemorrhagic disease of the newborn (HDN) at a tertiary care pediatric hospital of Morelos state.
Material And Methods:
A retrospective case series study was conducted between 1997-2000 at Hospital del Niño Morelense (Morelos State Children's Hospital), in 46 newborns aged under 12 weeks. Study subjects were referred from peripheral units with a diagnosis of HDN.
Results:
The severe late-onset form of HDN was present in 91% of the cases. Fifty-two percent of childbirths were assisted by a physician and 48% by an empiric midwife. Application of vitamin K was unknown in 61% of cases, in 39% it was not applied and in 4% it was applied. The majority of infants presented severe symptoms due to intra-cranial bleeding, 11% died, and 41% had severe disease sequelae.
Conclusions:
Given the high prevalence of HDN in the State of Morelos, reproductive health programs should be reviewed and training programs intensified to promote the utilization of vitamin K by physicians and nurses for preventing this disease.
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