Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lipid rafts and B-cell activation.

Susan K Pierce1

  • 1National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Immunogenetics, Twinbrook II, 12441 Parklawn Drive, Room 200B, MSC 8180, Rockville, Maryland 20852, USA. spierce@nih.gov

Nature Reviews. Immunology
|March 26, 2002
PubMed
Summary

Lipid rafts are crucial for B-cell receptor (BCR) signaling and antigen transport during B-cell activation. These membrane microdomains play a key role in regulating BCR function in development and viral infections.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Safety, Tolerability, and Pharmacokinetics of 6-Diazo-5-Oxo-L-Norleucine in Malawian Adults With and Without Malaria: A Phase 1 Dose-Escalation Clinical Trial.

The Journal of infectious diseases·2026
Same author

Human naïve B cells show evidence of anergy and clonal redemption following vaccination.

NPJ vaccines·2025
Same author

In the activation of HPV-specific human B cells HPV-VLP vaccines mimic membrane-associated antigens.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Isotype switching in human memory B cells sets intrinsic antigen-affinity thresholds that dictate antigen-driven fates.

Proceedings of the National Academy of Sciences of the United States of America·2024
Same author

DON in pediatric cerebral malaria, a phase I/IIA dose-escalation safety study: study protocol for a clinical trial.

Trials·2024
Same author

B cell responses to membrane-presented antigens require the function of the mechanosensitive cation channel Piezo1.

Science signaling·2023

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • The B-cell antigen receptor (BCR) initiates signaling and internalizes antigens for processing during B-cell activation.
  • Membrane microdomains, known as lipid rafts, are increasingly recognized for their role in cellular processes.

Purpose of the Study:

  • To explore the role of lipid rafts in B-cell activation, signaling, and antigen trafficking.
  • To understand how lipid rafts contribute to the regulation of the BCR.

Main Methods:

  • This study is based on recent evidence and existing research findings.
  • Analysis of the functional implications of lipid rafts in B-cell signaling pathways.

Main Results:

  • Lipid rafts serve as platforms for BCR signaling initiation.
  • Lipid rafts are implicated in antigen trafficking into B-cells.
  • These microdomains may regulate BCR function during B-cell development and in response to viral infections.

Conclusions:

  • Lipid rafts are integral to B-cell activation, influencing both signaling and antigen handling.
  • Understanding lipid rafts provides new insights into the complex B-cell signaling network.

Related Experiment Videos