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Updated: Oct 2, 2026

Tissue Preparation and Immunostaining of Mouse Sensory Nerve Fibers Innervating Skin and Limb Bones
Published on: January 26, 2012
Impairment of peripheral sensory innervation in senescence
B Ulfhak1, E Bergman, B T Fundin
1Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden. brun.ulfhake@neuro.ki.se
Abstract:
Sensorimotor disturbances are common among elderly and one of the main factors depreciating life quality in senescence. Mechanistically sensory deficits during aging include not only degenerative and regressive events but also phenotypic switches among sensory neurons as well as remodeling of sensory innervation. The pattern of changes suggests that an underlying mechanism is a sustained dependence of sensory neurons on target tissues, and that this dependence, at least in part, appears to be mediated through signaling by target-derived trophic factors. This review presents and discusses evidence supporting this notion.
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