Impairment of peripheral sensory innervation in senescence

Sensorimotor disturbances are common among elderly and one of the main factors depreciating life quality in senescence. Mechanistically sensory deficits during aging include not only degenerative and regressive events but also phenotypic switches among sensory neurons as well as remodeling of sensory innervation. The pattern of changes suggests that an underlying mechanism is a sustained dependence of sensory neurons on target tissues, and that this dependence, at least in part, appears to be mediated through signaling by target-derived trophic factors. This review presents and discusses evidence supporting this notion.