Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Protein interaction-targeted drug discovery: evaluating critical issues.

Erica A Golemis1, Kenneth D Tew, Disha Dadke

  • 1Fox Chase Cancer Center, Philadelphia, PA 19111, USA. ea_golemis@fccc.edu

Biotechniques
|March 26, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Small-Molecule Targeting of VDAC Disrupts Mitochondrial Bioenergetics and Suppresses Melanoma Cell Survival and Migration.

Cells·2026
Same author

Rescuing the Function of Missense-Mutated Tumor Suppressor <i>VHL</i> using Stabilizing Small Molecules.

bioRxiv : the preprint server for biology·2026
Same author

Small molecule inhibition of voltage dependent anion channel 1 reroutes mitochondrial metabolite flux.

Molecules and cells·2026
Same author

Role of SCAP in regulation of pancreatic homeostasis, pancreatitis, and tumorigenesis.

Oncogene·2026
Same author

NN-01-195, a novel conjugate of HSP90 and AURKA inhibitors, effectively targets solid tumors.

Molecular cancer therapeutics·2026
Same author

Michael addition drugs and cancer.

Advances in cancer research·2025

Developing small molecules to inhibit protein-protein interactions (PPIs) shows promise for drug discovery. Further research is needed to enhance prediction of drug binding properties and specificity for molecules under 500 Da.

Area of Science:

  • Drug development and validation
  • Molecular biology
  • Medicinal chemistry

Background:

  • Protein-protein interactions (PPIs) play crucial roles in cellular signaling pathways.
  • Targeting PPIs offers a promising avenue for novel therapeutic strategies.
  • Current limitations exist in predicting drug-target interactions based on structural data.

Purpose of the Study:

  • To explore the potential of small molecules targeting PPIs in drug development.
  • To identify key challenges and future directions in PPI-based drug design.
  • To discuss strategies for enhancing the specificity and efficacy of drug candidates.

Main Methods:

  • Literature review and general discussion of decision strategies in drug development.
  • Analysis of current limitations in structural databases for predicting protein binding.

Related Experiment Videos

  • Consideration of molecular size constraints for drug specificity.

    • Main Results:

    • Small molecule inhibitors of PPIs represent a significant long-term potential for drug development.
    • Advancements in structural databases are expected to improve the prediction of drug binding properties.
    • Determining the achievable specificity for small molecules (<500 Da) remains a key challenge.

    Conclusions:

    • Integrating PPI-targeting strategies with other drug design approaches can broaden the scope of targeted signaling pathways.
    • Systematic identification of protein interactions will be crucial as technologies advance.
    • Further research is warranted to overcome current limitations and fully realize the potential of PPI-based drug discovery.