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The phosphatidylinositol 3-phosphate-binding FYVE finger
Harald Stenmark1, Rein Aasland, Paul C Driscoll
1Department of Biochemistry, The Norwegian Radium Hospital, Oslo, Norway. h.a.stenmark@farmasi.uio.no
FEBS Letters
|March 26, 2002
Abstract:
The FYVE zinc finger domain is conserved from yeast (five proteins) to man (27 proteins). It functions in the membrane recruitment of cytosolic proteins by binding to phosphatidylinositol 3-phosphate (PI3P), which is found mainly on endosomes. Here we review recent work that sheds light on the targeting of FYVE finger proteins to PI3P-containing membranes, and how these proteins serve to regulate multiple cellular functions.