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Updated: Aug 5, 2026

Analysis of DNA Double-strand Break (DSB) Repair in Mammalian Cells
Published on: September 8, 2010
A repressible DNA-repair system in mouse neuroblastoma cells
Abstract:
Differentiated mouse neuroblastoma cells are extremely sensitive to UV light even through they can undergo excision-repair. A postreplication repair system present in proliferating cells is reversibly repressed in differentiated neuroblasts, and its genetic control is not coupled directly with DNA replication.
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Nucleotide Excision Repair
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
DNA Damage Can Stall the Cell Cycle