Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Performing Electroconvulsive Therapy and Assessing Seizure Efficacy via Pupillary Response02:22

Performing Electroconvulsive Therapy and Assessing Seizure Efficacy via Pupillary Response

299
Source: Shirozu, K., et al. Pupillary Response as Assessment of Effective Seizure Induction by Electroconvulsive Therapy. J. Vis. Exp. (2019)This video demonstrates the procedure for performing electroconvulsive therapy in a human patient, highlighting the stimulation process and assessing seizure activity through pupillary...
299
Inducing an Acute Electroconvulsive Seizure in a Rat Model02:33

Inducing an Acute Electroconvulsive Seizure in a Rat Model

348
Source: Jang, S., et al, Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins. J. Vis. Exp. (2017)This video demonstrates the induction of an acute electroconvulsive seizure (ECS) in a rat model to study seizure-induced neuroplasticity. Researchers apply electrical stimulation via ear-clip electrodes, triggering neuronal hyperexcitability and clonus. This model helps investigate synaptic plasticity, seizure...
348
Pupillary Response as Assessment of Effective Seizure Induction by Electroconvulsive Therapy04:51

Pupillary Response as Assessment of Effective Seizure Induction by Electroconvulsive Therapy

10.2K
Pupillary responses (light reflex) were measured for assessment of adequate seizure induction by electroconvulsive therapy using an automated infrared pupillometer immediately after electrical stimulation. Constriction ratio was calculated and compared with seizure...
10.2K
The Optical Fractionator Technique to Estimate Cell Numbers in a Rat Model of Electroconvulsive Therapy07:55

The Optical Fractionator Technique to Estimate Cell Numbers in a Rat Model of Electroconvulsive Therapy

12.1K
Here, we present a stereological method, the optical fractionator, used to quantify the formation of new neurons, and their survival, in the rat hippocampus following electroconvulsive stimulation. When correctly implemented, the sensitivity and efficiency of stereological methods ensures accurate estimates with a fixed and predetermined...
12.1K
Electroconvulsive Therapy01:30

Electroconvulsive Therapy

947
Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
947
Inhaled Medications01:23

Inhaled Medications

757
Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...
757

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The efficacy of clinical hypnosis in treating NREM and REM parasomnias: A retrospective study.

Sleep medicine·2026
Same author

Outreach Models for Substance Use Disorder in Homeless Populations: A Systematic Review and Network Meta-Analysis.

Psychiatric services (Washington, D.C.)·2026
Same author

Clinical and biological distinctions between catatonia due to a medical condition and catatonia associated with a psychiatric disorder.

General hospital psychiatry·2025
Same author

Corrigendum to "Functional neuroimaging in patients with catatonia: A systematic review". [Journal of Psychosomatic Research. 179 (2024) 111640].

Journal of psychosomatic research·2025
Same author

Resilient living program for patients with advanced cancer and their caregivers.

Palliative & supportive care·2025
Same author

Electroconvulsive therapy for the acute management of severe agitation in dementia (ECT-AD): A modified study protocol.

PloS one·2024
Same journal

Digital Mental Health: Progress but not Perfection.

The Psychiatric clinics of North America·2026
Same journal

Advances in Mental Health Technology.

The Psychiatric clinics of North America·2026
Same journal

The Future of Digital Mental Health: A Literature Review.

The Psychiatric clinics of North America·2026
Same journal

Assessment and Treatment of Posttraumatic Stress Disorder via Digital Mental Health Technology.

The Psychiatric clinics of North America·2026
Same journal

Treatment of Obsessive-Compulsive Disorder via Mental Health Technology.

The Psychiatric clinics of North America·2026
Same journal

Digital Mental Health Treatments for Depression.

The Psychiatric clinics of North America·2026
See all related articles

Related Experiment Video

Updated: Jan 20, 2026

Performing Electroconvulsive Therapy and Assessing Seizure Efficacy via Pupillary Response
02:22

Performing Electroconvulsive Therapy and Assessing Seizure Efficacy via Pupillary Response

Published on: August 28, 2025

299

Electroconvulsive therapy in the medically ill.

Keith G Rasmussen1, Teresa A Rummans, Jarrett W Richardson

  • 1Departments of Psychiatry and Psychology, Mayo Medical School, Rochester, Minnesota, USA. rasmussen.keith@mayo.edu

The Psychiatric Clinics of North America
|March 27, 2002
PubMed
Summary
This summary is machine-generated.

Electroconvulsive therapy (ECT) effectively treats severe psychiatric disorders, even with co-occurring medical or neurological conditions. Careful management minimizes potential complications, making ECT a viable option for complex patient cases.

More Related Videos

Pupillary Response as Assessment of Effective Seizure Induction by Electroconvulsive Therapy
04:51

Pupillary Response as Assessment of Effective Seizure Induction by Electroconvulsive Therapy

Published on: April 11, 2019

10.2K
Electroconvulsive Therapy
01:30

Electroconvulsive Therapy

947

Related Experiment Videos

Last Updated: Jan 20, 2026

Performing Electroconvulsive Therapy and Assessing Seizure Efficacy via Pupillary Response
02:22

Performing Electroconvulsive Therapy and Assessing Seizure Efficacy via Pupillary Response

Published on: August 28, 2025

299
Pupillary Response as Assessment of Effective Seizure Induction by Electroconvulsive Therapy
04:51

Pupillary Response as Assessment of Effective Seizure Induction by Electroconvulsive Therapy

Published on: April 11, 2019

10.2K
Electroconvulsive Therapy
01:30

Electroconvulsive Therapy

947

Area of Science:

  • Neuroscience
  • Psychiatry
  • Clinical Medicine

Background:

  • Severe psychiatric disorders often present with complex medical or neurological comorbidities.
  • Electroconvulsive therapy (ECT) is a recognized treatment for severe mental illness.
  • Managing psychiatric conditions alongside other health issues requires careful therapeutic consideration.

Purpose of the Study:

  • To evaluate the efficacy of Electroconvulsive therapy (ECT) in patients with psychiatric disorders and comorbid medical or neurologic conditions.
  • To assess the safety and complication profile of ECT in this specific patient population.

Main Methods:

  • Review of existing case series and case reports on ECT use in patients with comorbidities.
  • Analysis of psychopathology treatment outcomes in the presence of medical or neurologic conditions.
  • Examination of monitoring and precaution protocols during and after ECT administration.

Main Results:

  • Electroconvulsive therapy (ECT) demonstrates effectiveness in treating severe psychiatric disorders, irrespective of co-existing medical or neurologic comorbidities.
  • Available data, primarily from case studies, support the therapeutic benefits of ECT in complex patient profiles.
  • Implementation of specific precautions and vigilant monitoring can significantly reduce the incidence of ECT-related complications.

Conclusions:

  • Electroconvulsive therapy (ECT) remains a necessary and effective treatment option for severe psychiatric disorders, even when complicated by other medical or neurological issues.
  • The risks associated with ECT can be effectively managed through meticulous patient monitoring and adherence to safety protocols.
  • Further research, potentially including larger controlled studies, could further elucidate optimal ECT practices in comorbid populations.