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Updated: Oct 2, 2026
Aqueous Humor as a Liquid Biopsy for Retinoblastoma: Clear Corneal Paracentesis and Genomic Analysis
Published on: September 7, 2021
[Prognosis of retinoblastoma. Report of 50 cases]
H Bouguila1, I Malek, C Boujemâa
1Service du Pr S. Ayed, Institut Hédi Raïes d'Ophtalmologie de Tunis, Bab Saadoun, Tunis.
Purpose:
The aim of this study was to analyze the factors influencing the prognosis of retinoblastoma.
Materials And Methods:
In 50 children with retinoblastoma, 69 eyes were reviewed. All patients had a full ophthalmic examination, a B-scan ultrasound, a computerized tomography scan and a pediatric examination. We performed enucleation in 47 eyes (with a histopathological study), external beam irradiation in 16 eyes, curitherapy in 4 eyes, cryotherapy in 3 eyes, and adjuvant chemotherapy in 7 cases.
Results:
The global survival rate was 87.5%. The main aggravating factors were: the size of the tumor and the extraretinal involvement with extension within the chroid, the sclera, and the optic nerve.
Conclusion:
The prognosis of retinoblastoma mainly depends on the extraretinal invasion.
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