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Related Experiment Videos

Human verbal working memory impairments associated with thalamic damage.

D Dagenbach1, A K Kubat-Silman, J R Absher

  • 1Dept. of Psychology, Wake Forest University, Winston-Salem, NC 27109, USA. dagenbac@wfu.edu

The International Journal of Neuroscience
|March 27, 2002
PubMed
Summary

The thalamus plays a role in working memory, as evidenced by impairments in individuals with thalamic stroke on specific working memory tasks. This challenges previous findings of minimal deficits after thalamic damage.

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Area of Science:

  • Neuroscience
  • Cognitive Psychology

Background:

  • Theoretical models and animal studies suggest the thalamus is involved in working memory.
  • However, human studies show limited evidence of working memory deficits after thalamic lesions.

Purpose of the Study:

  • To investigate the role of the thalamus in human working memory.
  • To examine working memory performance in individuals with isolated thalamic stroke.

Main Methods:

  • Assessed working memory in six individuals with isolated thalamic stroke.
  • Utilized various working memory span tasks, including forward digit span, spatial, and object working memory assessments.
  • Conducted functional neuroimaging analysis.

Main Results:

  • Individuals with thalamic stroke showed impairments on several working memory span tasks.

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  • No significant deficits were observed on a forward digit-span measure.
  • Further analysis of different working memory aspects and lesion sites supported the thalamus's role.

    • Conclusions:

    • The thalamus is implicated in working memory function.
    • Thalamic lesions can lead to specific working memory deficits, contrary to some previous observations.