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Related Experiment Videos

Multiple ring-enhancing lesions in a child with relapsing multiple sclerosis.

Ching H Wang1, Kristen Walsh

  • 1Department of Psychiatry and Neurology, University of Missouri-Columbia, 65212, USA. wangc@health.missouri.edu

Journal of Child Neurology
|March 27, 2002
PubMed
Summary

Multiple ring-enhancing lesions on brain MRI, previously unreported in pediatric multiple sclerosis, were observed in a 14-year-old girl. This finding suggests pediatric multiple sclerosis should be considered in differential diagnoses for such cases.

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Area of Science:

  • Neurology
  • Radiology
  • Pediatrics

Background:

  • Ring-enhancing lesions in brain MRIs typically suggest infection but can occur in multiple sclerosis.
  • While reported in adults, multiple ring-enhancing lesions have not been previously documented in childhood multiple sclerosis.

Observation:

  • A 14-year-old girl presented with recurrent neurological symptoms and multiple ring-enhancing lesions on brain MRI.
  • Extensive infectious workup was negative; cerebrospinal fluid analysis revealed elevated myelin basic protein and oligoclonal bands.
  • Electrophysiologic studies indicated a demyelinating process.

Findings:

  • The patient responded to corticosteroids but relapsed, with new active lesions appearing on repeat MRI.
  • This case demonstrates that multiple ring-enhancing lesions can manifest in pediatric multiple sclerosis.

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  • Cerebrospinal fluid findings supported a diagnosis of demyelination.

    • Implications:

    • Multiple ring-enhancing lesions on brain MRI should be considered in the differential diagnosis of pediatric neurological conditions.
    • This case expands the understanding of radiographic presentations of childhood multiple sclerosis.
    • Highlights the importance of considering demyelinating diseases in pediatric patients with unexplained ring-enhancing brain lesions.