Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

B cell signaling. Introduction.

T Tsubata1, J Wienands

  • 1Department of Immunology, Medical Research Institute, Tokyo Medical and Dental University, Japan.

International Reviews of Immunology
|March 27, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impaired development of B cells with <i>PRF1</i> variants in an adult.

Scandinavian journal of rheumatology·2023
Same author

CD22 and CD72 are inhibitory receptors dominantly expressed in B lymphocytes and regulate systemic autoimmune diseases : English version.

Zeitschrift fur Rheumatologie·2016
Same author

[CD22 and CD72 are inhibitory receptors dominantly expressed in B lymphocytes and regulate systemic autoimmune diseases. German version].

Zeitschrift fur Rheumatologie·2016
Same author

PDK1 controls upstream PI3K expression and PIP3 generation.

Oncogene·2013
Same author

High-affinity ligands of Siglec receptors and their therapeutic potentials.

Current medicinal chemistry·2011
Same author

Regulation of in vitro and in vivo immune functions by the cytosolic adaptor protein SKAP-HOM.

Molecular and cellular biology·2005
Same journal

Leptin in metabolic-immune crosstalk: Mechanisms of T cell regulation and implications for autoimmune disease therapy.

International reviews of immunology·2026
Same journal

Metabolic alterations in the tumor microenvironment influence the anti-tumor immune function of CD8<sup>+</sup> T cells via epigenetic modifications.

International reviews of immunology·2026
Same journal

Macrophage markers and gene signature profiling reveals mesenchymal stem cells mediated immune modulation in Plasmodium berghei ANKA infection.

International reviews of immunology·2026
Same journal

Natural antigen landscape shaping intestinal Treg cells: Self, diet, and microbiota.

International reviews of immunology·2026
Same journal

Upregulation of ADAM10 reinforces CD8<sup>+</sup> T cells toward exhaustion in the TME.

International reviews of immunology·2026
Same journal

PTX3 promotes macrophage efferocytosis and inflammation resolution in granulomatous mastitis.

International reviews of immunology·2026
See all related articles

The B cell antigen receptor (BCR) complex, crucial for immune responses, transmits signals via lipid rafts involving kinases and co-receptors. This review explores BCR signaling pathways and regulatory mechanisms.

Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Signaling

Background:

  • The B cell antigen receptor (BCR) complex comprises immunoglobulin (Ig) for antigen recognition and Ig-alpha/Ig-beta for signaling.
  • BCR signaling dictates B cell fate, influencing gene expression, adhesion, and survival upon antigen encounter.
  • Proximal BCR signaling initiates in lipid rafts, involving key tyrosine kinases (Lyn, Syk, Btk) and SLP65/BLNK.

Purpose of the Study:

  • To provide a comprehensive overview of B cell antigen receptor (BCR) signaling pathways.
  • To discuss the regulatory mechanisms governing BCR signal transduction.
  • To highlight the roles of co-receptors and viral proteins in modulating BCR signaling.

Main Methods:

  • This review synthesizes existing research on BCR signaling.

Related Experiment Videos

  • It integrates findings on proximal and distal signaling cascades.
  • It discusses the involvement of membrane microdomains, kinases, adapter proteins, co-receptors, and viral proteins.

    • Main Results:

    • BCR signaling is initiated in lipid rafts and involves a network of kinases and adapter proteins.
    • Distal signaling pathways are complex and involve lipid kinases and small G-proteins.
    • Co-receptors like CD19 and CD22, and viral proteins like LMP2, significantly regulate BCR signaling.

    Conclusions:

    • BCR signaling is a tightly regulated process essential for normal immune function.
    • Understanding BCR signaling mechanisms is critical for comprehending B cell responses and immune regulation.
    • Further elucidation of distal signaling cascades and regulatory interactions is warranted.