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Childhood chronic immune thrombocytopenic purpura (ITP)
1Department of Hematology/Oncology, Hospital for Sick Children, Toronto, Ontario, Canada. victor.blkanchette@sickkids.ca
Blood Reviews
|March 27, 2002
Abstract:
Chronic immune thrombocytopenic purpura (ITP) develops in approximately 20% of children with acute ITP. Treatment requires differentiating the truly idiopathic state from thrombocytopenias associated with other disorders. Treatment is recommended in cases where platelet counts drop below 20 x 10(9)/L. Therapeutic options include corticosteroids, intravenous immunoglobulin TG(i.v.Ig), and anti-D, as well as splenectomy. The benefits and disadvantages of each modality are reviewed, as well as the management of postsplenectomy failures.