Pharmacogenetics of bipolar disorder
Related Experiment Video
Updated: Oct 2, 2026

Developing a Rat Model for Bipolar Disorder
Published on: May 2, 2025
Hader A Mansour1, Martin Alda, Vishwajit L Nimgaonkar
1Western Psychiatric Institute and Clinic, 3811 O'Hara Street, Room 443, Pittsburgh, PA 15213, USA.
Abstract:
To review the pharmacogenetics of bipolar disorders, the authors searched databases for genetic association and linkage studies involving response to long-term prophylactic lithium treatment, as well as treatment with antidepressants or clozapine. Significant ethnic variations in the metabolism and efficacy of antidepressants, as well as clozapine, have been reported by several groups. Systematic studies suggest that that genetic factors affect the response to prophylactic lithium treatment. Numerous associations between the three traits of interest and candidate gene polymorphisms have been proposed. Among these, an association between the serotonin transporter gene and response to serotonin reuptake inhibitors appears robust. Considerable interest has also focused on serotonergic gene polymorphisms and response to clozapine. Response to pharmacotherapy in bipolar disorders may be mediated by genetic factors, but the role played by heritability is unknown.
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