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Updated: Aug 9, 2026

Retrograde Perfusion and Filling of Mouse Coronary Vasculature as Preparation for Micro Computed Tomography Imaging
10:16

Retrograde Perfusion and Filling of Mouse Coronary Vasculature as Preparation for Micro Computed Tomography Imaging

Published on: February 10, 2012

Comparison of Triosil 370 with Urografin 76 and Hypaque 65 for coronary arteriography

D Verel, C Ward, M Aman

    British Heart Journal
    |October 1, 1975
    PubMed

    Insights

    Triosil 370 caused fewer cardiac electrical changes during coronary arteriography compared to Urografin 76 and Hypaque 65. This study highlights Triosil

    Area of Science:

    • Cardiovascular medicine
    • Radiology
    • Pharmacology

    Background:

    • Coronary arteriography requires contrast media for visualization.
    • Iodinated contrast agents can induce cardiac electrical changes.
    • Assessing the cardiac safety of contrast media is crucial.

    Purpose of the Study:

    • To compare the cardiac electrical effects of Triosil 370 with Urografin 76 and Hypaque 65.
    • To evaluate the safety profile of Triosil 370 in coronary arteriography.

    Main Methods:

    • Identical volumes of Triosil 370, Urografin 76, and Hypaque 65 were injected into the coronary arteries of human subjects.
    • Cardiac electrical activity (ST segment and T wave) was monitored during coronary arteriography.
    • Injection order was alternated, and procedural conditions were standardized.

    Main Results:

    • Triosil 370 induced significantly less ST segment and T wave deviation compared to Urografin 76 and Hypaque 65.
    • Quantitative analysis showed T wave deflection ratios of Triosil:Hypaque:Urografin as 1:2.6:2.9.
    • Triosil 370 demonstrated a more favorable cardiac electrical profile.

    Conclusions:

    • Triosil 370 exhibits a superior safety profile regarding cardiac electrical disturbances in coronary arteriography.
    • The findings suggest Triosil 370 may be a preferable contrast agent for patients undergoing coronary arteriography.
    • Further research could explore long-term effects and patient outcomes.

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