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Peroxisome proliferator-activated receptor alpha gene variants influence progression of coronary atherosclerosis and

David M Flavell1, Yalda Jamshidi, Emma Hawe

  • 1Centre for Cardiovascular Genetics, Department of Medicine, Royal Free and University College of London Medical School, London, UK. d.flavell@ucl.ac.uk

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|March 27, 2002
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The PPARalpha gene influences atherosclerosis and ischemic heart disease (IHD) risk. Specific gene variants affect disease progression, suggesting direct effects on blood vessels, not just lipid levels.

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Area of Science:

  • Cardiovascular Genetics
  • Molecular Medicine
  • Atherosclerosis Research

Background:

  • Peroxisome proliferator-activated receptor alpha (PPARalpha) is crucial for lipid metabolism and inflammation.
  • PPARalpha is implicated in the development of atherosclerosis and ischemic heart disease (IHD).

Purpose of the Study:

  • To investigate the association of PPARalpha gene polymorphisms (L162V and intron 7 G/C) with atherosclerosis progression and IHD risk.
  • To determine if PPARalpha gene variants impact plasma lipid concentrations or directly affect vascular disease.

Main Methods:

  • Analysis of PPARalpha L162V and intron 7 G/C polymorphisms in the LOCAT and NPHS2 studies.
  • Assessment of atherosclerosis progression and IHD risk in relation to PPARalpha genotypes.
  • Evaluation of associations with plasma lipid concentrations.

Main Results:

  • Neither PPARalpha polymorphism correlated with plasma lipid concentrations.
  • Both L162V and intron 7 G/C polymorphisms were associated with atherosclerosis progression and IHD risk.
  • The V162 allele of L162V and the C allele of intron 7 showed distinct effects on atherosclerosis, with V162 potentially mitigating the proatherosclerotic impact of the intron 7 C allele.

Conclusions:

  • The PPARalpha gene significantly influences atherosclerosis progression and IHD risk.
  • The lack of association with lipid levels suggests PPARalpha exerts its effects directly within the vessel wall.
  • Specific PPARalpha gene variants modulate cardiovascular disease risk independently of lipid profiles.