Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cochlear transduction: from models to molecules and back again.

Jonathan F Ashmore1, Jean-Marie Chambard, Sarah Richmond

  • 1Department of Physiology, University College London, UK. j.ashmore@ucl.ac.uk

Audiology & Neuro-Otology
|March 27, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

OzBarley: A genetic and phenotypic data resource capturing the Australian barley breeding history.

Scientific data·2026
Same author

Quantitative assessment of the usability of electromechanical human-based modelling and simulation to replace Langendorff isolated rabbit heart experiments in the preclinical setting.

Frontiers in pharmacology·2025
Same author

Vulnerable road user injury trends following the COVID-19 pandemic in Toronto, Canada: An interrupted time series analysis.

Journal of safety research·2024
Same author

The Remarkable Outer Hair Cell: Proceedings of a Symposium in Honour of W. E. Brownell.

Journal of the Association for Research in Otolaryngology : JARO·2023
Same author

Design of Crotoxin-Based Peptides with Potentiator Activity Targeting the ΔF508NBD1 Cystic Fibrosis Transmembrane Conductance Regulator.

Journal of molecular biology·2022
Same author

Accurate in silico simulation of the rabbit Purkinje fiber electrophysiological assay to facilitate early pharmaceutical cardiosafety assessment: Dream or reality?

Journal of pharmacological and toxicological methods·2022

Researchers are unraveling cochlear function, focusing on sensory transduction in the mammalian cochlea. Identifying motor proteins like prestin in outer hair cells (OHCs) offers insights into cochlear tuning and hair cell stability.

Area of Science:

  • Otoacoustic Emissions and Auditory Neuroscience
  • Molecular and Cellular Biology
  • Genomics and Bioinformatics

Background:

  • Significant progress in cochlear function understanding remains incomplete.
  • Integrating molecular, genetic, and genomic data requires robust theoretical models.
  • Sensory transduction at the mammalian cochlea's basal end is a key unresolved area.

Purpose of the Study:

  • To investigate the mechanisms of sensory transduction in the mammalian cochlea.
  • To explore the role of motor proteins in outer hair cells (OHCs) and cochlear tuning.
  • To elucidate the molecular basis of OHC function and hair cell stability.

Main Methods:

  • Analysis of molecular, genetic, and genomic data.
  • Theoretical modeling of cochlear physiology.

Related Experiment Videos

  • Identification and characterization of candidate motor proteins in OHCs.

    • Main Results:

    • The motor protein 'prestin' is associated with an anion transporter superfamily.
    • This association provides insights into the molecular nature of the OHC motor.
    • Chloride utilization in hair cells and the stability of basal turn cochlear hair cells are implicated.

    Conclusions:

    • Understanding OHC motor function is crucial for explaining cochlear tuning.
    • Prestin's role as an anion transporter sheds light on OHC mechanotransduction.
    • Further research is needed to fully integrate molecular findings with cochlear physiology.