Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mechanical transduction in outer hair cells.

Antony W Gummer1, Jens Meyer, Gerhard Frank

  • 1Department of Otolaryngology, Section Physiological Acoustics and Communication, University of Tübingen, Germany. anthony.gummer@uni-tuebingen.de

Audiology & Neuro-Otology
|March 27, 2002
PubMed
Summary

Outer hair cells enhance hearing sensitivity through a mechanical feedback system. This system involves stereocilia and basolateral membrane mechanisms, crucial for cochlear function.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Author Correction: Optimal timing for antimicrobial prophylaxis to reduce surgical site infections: a retrospective analysis of 531 patients.

Scientific reports·2023
Same author

Optimal timing for antimicrobial prophylaxis to reduce surgical site infections: a retrospective analysis of 531 patients.

Scientific reports·2023
Same author

Parotid Gland Tumors: A Multicenter Analysis of 1020 Cases. Increasing Incidence of Warthin's Tumor.

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India·2022
Same author

Infectious hematogenous lumbar spondylodiscitis caused by Actinotignum schaalii in a 74-year-old man: A case report.

International journal of surgery case reports·2022
Same author

Examination of a Structural Preference in Quaternary Alkali-Metal (A) Rare-Earth (R) Copper Tellurides by Combining Experimental and Quantum-chemical Means.

Inorganic chemistry·2022
Same author

Inflammatory Pseudotumor in the Parapharyngeal Space: Is It Possible to Diagnose by Exclusion?

Cureus·2021

Area of Science:

  • Auditory Neuroscience
  • Mechanobiology
  • Cellular Physiology

Background:

  • Outer hair cells (OHCs) are critical for the cochlea's sensitivity, frequency selectivity, and dynamic range.
  • OHCs operate within a complex mechanical feedback system involving the basilar membrane and tectorial membrane.

Purpose of the Study:

  • To investigate the mechanical transduction mechanisms within the stereocilia of outer hair cells.
  • To explore the role of the basolateral cell membrane in outer hair cell function.
  • To understand how outer hair cell force is coupled to the organ of Corti.

Main Methods:

  • Experimental investigation of mechanical transduction in stereocilia.
  • Analysis of basolateral membrane mechanics.
  • Studies on the coupling mechanisms of outer hair cell force within the organ of Corti.

Related Experiment Videos

Main Results:

  • Demonstrated the role of stereocilia deflection in modulating transduction channel activity.
  • Identified the contribution of membrane potential changes to mechanical force generation.
  • Elucidated modes of force coupling from outer hair cells to the organ of Corti.

Conclusions:

  • Outer hair cells employ sophisticated mechanical feedback to achieve high auditory performance.
  • Understanding these mechanisms is key to comprehending normal hearing and hearing loss.
  • Further research into OHC mechanics can inform therapeutic strategies for auditory disorders.