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Related Experiment Videos

Serial analysis of the apparent diffusion coefficient time course in human stroke.

J B Fiebach1, O Jansen, P D Schellinger

  • 1Department of Neuroradiology, University of Heidelberg, Medical School, Kopfklinik, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany. Jochen_Fiebach@med.uni-heidelberg.de

Neuroradiology
|March 27, 2002
PubMed
Summary

Apparent diffusion coefficient (ADC) changes rapidly in acute ischemic stroke, aiding in stroke age determination. This diffusion-weighted MRI method helps distinguish single from multiple strokes.

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Area of Science:

  • Neurology
  • Radiology
  • Medical Imaging

Background:

  • Acute cerebral ischemic injury is detectable via diffusion-weighted imaging.
  • Apparent diffusion coefficient (ADC) reflects cytotoxic edema and water content in brain infarcts.

Purpose of the Study:

  • To determine the time course of ADC during the initial days of ischemic stroke.
  • To differentiate single progressive infarction from multiple strokes.

Main Methods:

  • Diffusion-weighted MRI was performed on eight patients within 20 hours of stroke onset.
  • ADC values were analyzed from 55 MRI studies over 10 days, comparing lesion to contralateral tissue (rADC).
  • Analysis was conducted separately for white and gray matter.

Main Results:

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  • A uniform reduction in rADC was observed from stroke onset, decreasing to day 3.
  • rADC increased from day 4, reaching pseudo-normalization by day 9.
  • Gray matter showed a slightly faster rADC increase than white matter.

Conclusions:

  • rADC exhibits significant, uniform changes in the early days post-stroke.
  • Combined with T2-weighted MRI, rADC can differentiate stroke ages (hyperacute, acute, chronic).
  • This method allows for determining stroke age and distinguishing multiple from single progressive strokes.