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Bisxanthones from Hypericum japonicum: inhibitors of PAF-induced hypotension
Kyoko Ishiguro1, Satoko Nagata, Hisae Oku
1School of Pharmaceutical Sciences, Mukogawa Women's University, Koshien Kyuban-cho, Hyogo, Japan. ishiguro@mwu.mukogawa-u.ac.jp
Planta Medica
|March 27, 2002
Abstract:
The CHCl3-soluble part (HJ) of the MeOH extract from Hypericum japonicum afforded new bisxanthones, jacarelhyperols A (1) and B (2). The structures were elucidated by spectral methods. These compounds and HJ showed significant inhibitory effects against PAF-induced hypotension by an in vivo evaluation method, which can reveal the pharmacological action of the test material.