[Intermittent fever of infectious origin]
Related Experiment Video
Updated: Oct 2, 2026

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
Published on: September 7, 2022
Vincent Le Moing1, Catherine Leport
1Service des maladies infectieuses et tropicales Hôpital Gui-de-Chauliac 34295 Montpellier. v-le_moing@chu-montpellier.fr
Abstract:
Intermittent fever is rare during the course of infectious diseases but it represents a diagnostic and therapeutic challenge. The most frequent infectious causes of intermittent fever are focal bacterial infections, mainly infections localised to canals like urinary or biliary ducts or the colon and also infections of a foreign material. Other causes are less frequent, like infective endocarditis, tuberculosis, infections due to Yersinia enterocolitica or malaria, or exceptional like borreliosis, ratbite fever, chronic meningococcemia or chronic Epstein-Barr Virus infection. Careful anamnesis and clinical examination as well as a few simple complementary investigations, preferably performed during a febrile episode, are often sufficient to set the limits of possible further more complex investigations.
Insights
Intermittent fever, though rare in infectious diseases, poses diagnostic challenges. Identifying common causes like focal bacterial infections and foreign material infections aids in managing this condition.
Area of Science:
- Infectious Diseases
- Internal Medicine
- Clinical Diagnostics
Context:
- Intermittent fever is an uncommon but challenging manifestation of infectious diseases.
- Requires careful diagnostic evaluation to identify underlying causes.
- Often associated with focal bacterial infections or foreign materials.
Purpose:
- To outline the diagnostic and therapeutic challenges posed by intermittent fever.
- To review the spectrum of infectious causes of intermittent fever.
- To emphasize the utility of initial clinical assessment and investigations.
Summary:
- Focal bacterial infections (urinary, biliary, colon) and foreign material infections are frequent causes.
- Less common causes include infective endocarditis, tuberculosis, Yersinia enterocolitica, and malaria.
- Rare causes encompass borreliosis, ratbite fever, chronic meningococcemia, and Epstein-Barr Virus infection.
- Initial patient history, clinical exam, and targeted investigations during fever are crucial.
Impact:
- Provides a framework for diagnosing intermittent fever.
- Guides clinicians toward appropriate investigations based on suspected etiology.
- Aids in efficient patient management, reducing the need for extensive testing.
Related Concept Videos
Patterns of Fever
Types of Fever
Here are the different types of fever:
Stages of Infection
Methods of reducing fever
Pharmacological Methods of Reducing Fever:
Increased Body Temperature
Encephalitis l: Introduction
