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SCID mouse models to study human cancer pathogenesis and approaches to therapy: potential, limitations, and future
Richard B Bankert1, Stephen D Hess, Nejat K Egilmez
1State University of New York at Buffalo, Department of Microbiology, 14214, USA. rbankert@buffalo.edu
Abstract:
The successful engraftment of human tumors and human immunocompetent cells into severe combined immunodeficient (SCID) mice has led to the generation of a wide array of different experimental designs that have proven useful in studying the cell biology of human cancer, and for evaluating novel therapeutic approaches to the treatment of cancer. In this review five of the most frequently used embodiments of the SCID model are presented. The goals of this review are to discuss how each model has been utilized to study human cancer and its response to many different novel therapies, to provide an assessment of the strengths and limitations of each model, and to outline future directions with a focus on what is needed to overcome some of the current limitations and pitfalls of the SCID models.
Insights
Severe combined immunodeficient (SCID) mice models enable human cancer research and therapeutic evaluation. This review assesses five common SCID models, their applications, and future directions for cancer studies.
Area of Science:
- Oncology
- Immunology
- Transplantation Biology
Background:
- Severe combined immunodeficient (SCID) mice allow engraftment of human tumors and immunocompetent cells.
- This capability has facilitated diverse experimental designs for cancer research and therapy evaluation.
Purpose of the Study:
- To review five frequently used SCID mouse models for human cancer research.
- To discuss their utility in studying cancer cell biology and novel therapeutic approaches.
- To assess the strengths, limitations, and future directions of these models.
Main Methods:
- Review of literature on SCID mouse models in cancer research.
- Analysis of experimental designs utilizing SCID models for cancer studies.
- Assessment of therapeutic evaluations conducted in SCID models.
Main Results:
- Five common SCID mouse model embodiments are presented.
- Each model's application in studying human cancer and its response to therapies is discussed.
- Strengths and limitations of each model are evaluated.
Conclusions:
- SCID models are valuable tools for human cancer research and drug development.
- Addressing current limitations is crucial for advancing future applications.
- Further refinement of SCID models will enhance their utility in oncology.