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Performance characteristics of putative tests for subclinical chorioamnionitis
R K Edwards1, P Clark, J Locksmith Gregory
1Department of Obstetrics and Gynecology, University of Florida College of Medicine, Gainesville 32610-0294, USA.
Infectious Diseases in Obstetrics and Gynecology
|March 28, 2002
Summary
Amniotic fluid glucose, matrix metalloproteinase (MMP)-9, and interleukin (IL)-6 effectively diagnose subclinical chorioamnionitis in preterm labor. Interleukin-12 did not show diagnostic value for this condition.
Area of Science:
- Obstetrics and Gynecology
- Maternal-Fetal Medicine
- Infectious Disease in Pregnancy
Background:
- Subclinical chorioamnionitis is a significant complication in preterm labor.
- Accurate diagnosis is crucial for timely intervention and improved outcomes.
Purpose of the Study:
- To assess the diagnostic utility of amniotic fluid glucose, MMP-9, IL-6, and IL-12 for subclinical chorioamnionitis in women with preterm labor.
Main Methods:
- Amniotic fluid was analyzed from 44 women in preterm labor (22-35 weeks gestation).
- Tests included Gram stain, culture, glucose, MMP-9, IL-6, and IL-12 levels.
- Statistical analysis compared analyte values with positive amniotic fluid culture or delivery within 24 hours.
Main Results:
- Amniotic fluid glucose, MMP-9, and IL-6 concentrations correlated significantly with positive cultures or delivery within 24 hours.
- Interleukin-12 levels did not show a correlation with either outcome measure.
Conclusions:
- Amniotic fluid glucose, MMP-9, and IL-6 are reliable biomarkers for detecting microbial invasion or predicting imminent delivery in preterm labor.
- Interleukin-12 is not a useful marker for diagnosing subclinical chorioamnionitis in this context.