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Related Experiment Videos

Nanotiterplates for combinatorial chemistry.

G Mayer1, A Schober, J M Köhler

  • 1Institut für Physikalische Hochtechnologie e.V. (IPHT), Jena, Germany.

Journal of Biotechnology
|March 28, 2002
PubMed
Summary
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Miniaturized reaction vessels called nanotiterplates are advancing chemical and biochemical labs. This research details their fabrication, applications in synthesis and screening, and addresses challenges like surface properties and solvent evaporation.

Area of Science:

  • Chemical Engineering
  • Biotechnology
  • Materials Science

Background:

  • Miniaturization is crucial for modern chemical and biochemical laboratories.
  • Drug discovery requires efficient synthesis and screening of new substances.
  • Miniaturization presents challenges such as surface properties and solvent evaporation.

Purpose of the Study:

  • To report on recent developments in miniaturized reaction vessels (nanotiterplates).
  • To survey fabrication technologies and applications of nanotiterplates.
  • To present results on an automaton for miniaturized synthesis and screening.

Main Methods:

  • Fabrication of nanotiterplates with integrated microsieve bottom membranes.
  • Characterization and surface property adaptation of nanotiterplates.

Related Experiment Videos

  • Investigation of solvent evaporation and prevention methods.

    • Main Results:

    • Successful fabrication of nanotiterplates with microsieve bottoms.
    • Demonstrated applications in chemical synthesis and bio-assays.
    • Characterization of surface properties and solvent evaporation dynamics.

    Conclusions:

    • Nanotiterplates offer a viable solution for miniaturized synthesis and screening.
    • Addressing surface properties and evaporation is key for effective miniaturized systems.
    • Further development of automated systems using nanotiterplates holds significant potential for drug discovery.