Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

G-protein-coupled receptor dimerization: modulation of receptor function.

C D Rios1, B A Jordan, I Gomes

  • 1Department of Pharmacology, New York University School of Medicine, MSB 408, 550 First Avenue, New York 10016, USA.

Pharmacology & Therapeutics
|March 28, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

X-chromosomal STRs: Metapopulations and mutation rates.

Forensic science international. Genetics·2025
Same author

The cascade of care for household contacts of people with drug-resistant TB.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2023
Same author

Impact of the COVID-19 pandemic on in-hospital diagnosis of tuberculosis in non-HIV patients.

Pulmonology·2022
Same author

Health-related quality of life of inpatients and outpatients with TB in rural Malawi.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2020
Same author

Multiple Drug Hypersensitivity Syndrome to Antituberculosis Drugs: A Case Report.

Journal of investigational allergology & clinical immunology·2019
Same author

Effect of Zirconia Pigmentation on Translucency.

The European journal of prosthodontics and restorative dentistry·2018

G-protein-coupled receptors (GPCRs) are now understood to form dimers and oligomers, challenging the long-held view that they function as monomers. This review explores techniques and implications of GPCR oligomerization.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Background:

  • G-protein-coupled receptors (GPCRs) are the largest transmembrane receptor family, crucial for cellular signaling.
  • Recent evidence suggests GPCRs exist as dimers or oligomers, contradicting the traditional monomeric function model.
  • Early studies predicted GPCR oligomerization, but technical limitations hindered investigation.

Purpose of the Study:

  • To review techniques used to study GPCR dimerization and oligomerization.
  • To discuss the functional implications of GPCR oligomerization.
  • To examine domains involved in GPCR assembly and their subcellular localization.

Main Methods:

  • Pharmacological studies
  • Biochemical techniques (cross-linking, immunoprecipitation)

Related Experiment Videos

  • Biophysical techniques (BRET, FRET) for in-cell analysis

    • Main Results:

    • Various techniques now allow visualization and functional assessment of GPCR oligomers.
    • GPCR dimerization/oligomerization has significant implications for receptor function.
    • Specific receptor domains are implicated in facilitating GPCR assembly.

    Conclusions:

    • GPCRs can form dimers and oligomers, impacting their signaling roles.
    • Advancements in techniques have enabled robust investigation of GPCR oligomerization.
    • Understanding GPCR assembly is key to deciphering their complex cellular functions.