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Updated: Sep 21, 2026

Evaluation of Polymeric Gene Delivery Nanoparticles by Nanoparticle Tracking Analysis and High-throughput Flow Cytometry
Published on: March 1, 2013
Gene delivery using temperature-responsive polymeric carriers
1Tokyo Women's Medical University, Institute of Advanced Biomedical Engineering and Science, Kawada-cho 8-1, Shinjuku-ku, Tokyo 162-8666, Japan. masajun@lab.twmu.ac.jp
Abstract:
Synthetic temperature-responsive polymers can be applied as gene carrier systems. For successful gene therapies, efficient and safe vectors are essential because they deliver genes to target cells and aid gene expression of therapeutic peptides. Vector systems that can control gene expression are favorable, especially for genes whose therapeutic effects are considerably dependent on quantity, site, duration and timing of their expression. Strategy and clinical feasibility of the temperature-responsive vector system are discussed with an example of gene expression enhancement by temperature stimuli.
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