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Related Experiment Videos

Non-bacterial thrombotic endocarditis.

V Markides1, P Nihoyannopoulos

  • 1National Heart & Lung Institute, Imperial College School of Medicine, Waller Cardiac Department, St Mary's Hospital, South Wharf Road, London W2 1NY, UK.

European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology
|March 28, 2002
PubMed
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A patient with cachexia and confusion had culture-negative endocarditis. Post-mortem revealed non-bacterial thrombotic endocarditis linked to metastatic signet-ring carcinoma, explaining the cerebral infarct.

Area of Science:

  • Cardiology
  • Oncology
  • Neurology

Background:

  • Non-bacterial thrombotic endocarditis (NBTE) is a rare condition often associated with malignancy.
  • Culture-negative endocarditis presents diagnostic challenges, particularly when malignancy is suspected.

Observation:

  • A 63-year-old male presented with cachexia and confusion, indicative of a serious underlying condition.
  • Cardiac examination revealed endocarditis of the aortic valve, which was culture-negative.

Findings:

  • Despite broad-spectrum antibiotics and thorough investigation, the patient experienced a large cerebral infarct and succumbed.
  • Autopsy confirmed non-bacterial thrombotic endocarditis (NBTE) and revealed a metastatic signet-ring carcinoma.

Implications:

Related Experiment Videos

  • This case highlights the critical association between NBTE and occult malignancy.
  • Early recognition of NBTE may prompt investigation for underlying cancers, potentially altering patient outcomes.
  • Signet-ring cell carcinoma should be considered in the differential diagnosis of patients with NBTE and unexplained systemic symptoms.