Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[GnRH antagonists in IVF].

F Olivennes1, R Fanchin, N Lédée

  • 1Service de Gynécologie-Obstétrique, Hôpital Antoine-Béclère, 157, rue de la Porte-de-Trivaux, 92140 Clamart.

Journal De Gynecologie, Obstetrique Et Biologie De La Reproduction
|March 29, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sinonasal mucosal melanoma: REFCOR guidelines for diagnosis, treatment and follow-up.

European annals of otorhinolaryngology, head and neck diseases·2026
Same author

Canadian Surgery Forum: Abstracts of presentations to the Annual Meetings of the Canadian Association of Bariatric Physicians and Surgeons, Canadian Association of General Surgeons, Canadian Association of Thoracic Surgeons, Canadian Hepato-Pancreato-Biliary Association, Canadian Society of Surgical Oncology, Canadian Society of Colon and Rectal Surgeons, Vancouver, BC, Sept. 17-21, 2013.

Canadian journal of surgery. Journal canadien de chirurgie·2025
Same author

Fluorescence angiography with indocyanine green for low anterior resection in patients with rectal cancer: a prospective before and after study.

Techniques in coloproctology·2025
Same author

Towards the standardization of Hydra vulgaris bioassay for toxicity assessments of liquid samples.

Ecotoxicology and environmental safety·2024
Same author

A letter to the editor: Okay, but what for?

European annals of otorhinolaryngology, head and neck diseases·2024
Same author

Writing in the European Annals of Otorhinolaryngology Head & Neck Diseases. Dos and Don'ts!

European annals of otorhinolaryngology, head and neck diseases·2023
Same journal

[Neuroprotection for preterm infants with antenatal magnesium sulphate].

Journal de gynecologie, obstetrique et biologie de la reproduction·2017
Same journal

[Is universal screening for cervical length among singleton pregnancies with no history of preterm birth justified?]

Journal de gynecologie, obstetrique et biologie de la reproduction·2017
Same journal

[Lifestyle recommendations for prevention of spontaneous preterm birth in asymptomatic pregnant women].

Journal de gynecologie, obstetrique et biologie de la reproduction·2017
Same journal

[Guidelines for clinical practice: Prevention of spontaneous preterm birth (excluding preterm premature rupture of membranes) - Introduction].

Journal de gynecologie, obstetrique et biologie de la reproduction·2017
Same journal

[Psychological aspects of abortion].

Journal de gynecologie, obstetrique et biologie de la reproduction·2016
Same journal

[Induced abortion: Guidelines for clinical practice - Introduction].

Journal de gynecologie, obstetrique et biologie de la reproduction·2016
See all related articles

New gonadotropin-releasing hormone (GnRH) antagonists are effective in preventing the LH surge during IVF. They offer reduced stimulation length and fewer complications like OHSS compared to GnRH agonists.

Area of Science:

  • Reproductive Endocrinology
  • In Vitro Fertilization (IVF)

Background:

  • Gonadotropin-releasing hormone (GnRH) agonists have been standard for preventing the luteinizing hormone (LH) surge in IVF.
  • GnRH antagonists offer a newer approach to LH surge suppression.

Purpose of the Study:

  • To evaluate the efficacy and safety of new GnRH antagonists in clinical practice.
  • To compare two distinct GnRH antagonist administration protocols.

Main Methods:

  • Multiple dose regimen: 0.25 mg antagonist from stimulation day 5/6 until hCG.
  • Single dose protocol: 3 mg antagonist in the late follicular phase.
  • Comparison with GnRH agonists in long protocols.

Main Results:

  • Both GnRH antagonist protocols effectively prevent the LH surge.

Related Experiment Videos

  • Reduced stimulation length, gonadotropin consumption, and incidence of ovarian hyperstimulation syndrome (OHSS).
  • Comparable pregnancy rates in selected good-prognosis patients versus GnRH agonists.

    • Conclusions:

    • GnRH antagonists demonstrate good local and general tolerance.
    • These antagonists offer significant advantages in reducing complications and side effects of ovarian stimulation.
    • GnRH antagonists are poised to become important in IVF protocols.