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Updated: Oct 2, 2026

Busulfan as a Myelosuppressive Agent for Generating Stable High-level Bone Marrow Chimerism in Mice
Published on: April 1, 2015
Busulfan-induced loss of Ph chromosome in chronic myeloid leukemia
M Radojkovic1, S Ristic, M Colovic
1Clinic of Internal Medicine, Clinical Center Dr Dragisa Misovic, Belgrade, Yugoslavia. radojkov@EUnet.yu
Abstract:
We report a 44-yr-old female with Philadelphia chromosome positive chronic myeloid leukemia who was initially treated with busulfan, and clinical remission has been achieved. After 4 yr, low-dose busulfan therapy was started again and induced bone marrow aplasia. The patient spontaneously has recovered from aplasia, and complete cytogenetic remission with loss of Ph+ chromosome in bone marrow has been achieved. However, reverse-transcription-polymerase chain reaction analysis showed presence of the bcr-abl transcript in bone marrow.

