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Heparin-induced priapism.

T H Bschleipfer1, E W Hauck, T H Diemer

  • 1Department of Urology, Bundeswehrkrankenhaus Ulm, Germany.

International Journal of Impotence Research
|March 29, 2002
PubMed
Summary
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Heparin can cause prolonged erections (priapism) through antiplatelet antibodies affecting blood flow. Further research is needed to clarify the exact cause of heparin-induced priapism and its long-term effects.

Area of Science:

  • Urology
  • Pharmacology
  • Hematology

Background:

  • Heparin-induced priapism is a rare side effect of heparin therapy.
  • The exact pathophysiological mechanisms remain unclear.

Observation:

  • Heparin may trigger antiplatelet antibodies, leading to platelet aggregation.
  • Altered penile blood flow can result in low-flow priapism.
  • High-flow priapism might evolve into ischemic priapism.

Findings:

  • Platelet aggregation and altered penile hemodynamics are potential causes.
  • Hemorrhage, hematoma organization, and fibrosis are discussed as pathogenetic factors.
  • Differential diagnosis, diagnostic, and therapeutic strategies for priapism are presented.

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Implications:

  • Clarifying the pathophysiology of heparin-induced priapism is crucial for patient management.
  • Understanding the role of thrombosis and hemorrhage can guide treatment decisions.
  • This review provides a comprehensive overview for clinicians managing priapism.