Targeting the "species gene ensemble"
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Updated: Oct 2, 2026

A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research
Published on: August 16, 2017
1Cresap Neuroscience Laboratory, Department of Psychology, Institute for Neuroscience, Northwestern University, Evanston, Illinois 60208, USA. aryeh@northwestern.edu
Abstract:
The members of a given species display a normal distribution of gene expression which is here termed the species gene ensemble. This more specific designation of the 'genetic background' leads to a consideration of why gene targeting outcomes are regulated by the species gene ensemble. One consequence is the utility of the heterozygous knockout which buffers the drastic compensatory reactions of the homozygous knockout thereby revealing subtle but yet consistent alterations in hippocampally-dependent behaviors.
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