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Pyrogenic reactions following gentamicin therapy: an alternative explanation
1Department of Medicine, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA. bjaber@lifespan.org
Medical Hypotheses
|March 29, 2002
Abstract:
A hypothesis is proposed, arguing that gentamicin administration in a single daily dose results in higher peak tissue concentration, marked bacteriolysis with endotoxin (ET) release and consequent ET-mediated febrile host responses, which resemble Jarisch-Herxheimer reactions.