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Microalbuminuria in hypertension is not a determinant of insulin resistance

Ingrid Toft1, Kaare H Bønaa, Jorunn Eikrem

  • 1Division of Nephrology, Department of Internal Medicine, University Hospital of Tromsø, Tromsø, Norway. Ingridt@fagmed.uit.no

Kidney International
|March 29, 2002
PubMed
Abstract

Insights

Microalbuminuria (MA) in hypertension does not indicate insulin resistance when adiposity is controlled. This study found no direct link between MA and impaired insulin action in hypertensive individuals.

Area of Science:

  • Nephrology
  • Endocrinology
  • Cardiovascular Medicine

Background:

  • Microalbuminuria (MA) is linked to metabolic issues and cardiovascular disease risk in diabetes and hypertension.
  • MA may reflect endothelial damage, prompting investigation into its direct relationship with insulin action.

Purpose of the Study:

  • To determine if microalbuminuria (MA) is directly associated with impaired insulin action in untreated hypertension.
  • To investigate the relationship between MA and metabolic profiles, including insulin sensitivity.

Main Methods:

  • Eighty-four untreated hypertensive individuals were assessed for microalbuminuria (MA) using 24-hour urine samples.
  • Participants were categorized into MA and non-MA groups, matched for age, gender, and BMI. Insulin sensitivity was measured via clamp techniques.

Main Results:

  • The MA and non-MA groups showed no significant differences in fasting/post-load glucose, insulin levels, or insulin sensitivity indices.
  • The MA group exhibited higher systolic blood pressure and serum advanced glycation end products (AGEs).
  • No associations were found between MA and insulin sensitivity, glucose, or insulin levels; weak associations existed with systolic blood pressure, AGEs, and smoking.

Conclusions:

  • Microalbuminuria (MA) is not a determinant of insulin resistance in hypertension when confounding factors like adiposity are controlled.
  • The findings suggest that endothelial damage reflected by MA may not directly impair insulin action in this context.

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