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Related Experiment Videos

Sedation, cognition, and antihistamines.

Julie C Qidwai1, Ginger S Watson, John M Weiler

  • 1National Advanced Driving Simulator and Department of Internal Medicine, University of Iowa, 200 Hawkins Drive, Iowa City 52244, USA.

Current Allergy and Asthma Reports
|March 29, 2002
PubMed
Summary

First-generation antihistamines cause drowsiness and impair performance. Newer, second-generation antihistamines do not have these side effects, showing a clear difference in safety and efficacy.

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Area of Science:

  • Pharmacology
  • Neuroscience
  • Clinical Medicine

Background:

  • First-generation antihistamines are associated with subjective drowsiness.
  • Numerous studies indicate objective performance impairment linked to these older antihistamines.

Purpose of the Study:

  • To differentiate the effects of first-generation versus second-generation antihistamines on cognitive performance.
  • To highlight the safety profile differences between sedating and nonsedating antihistamines.

Main Methods:

  • Review of existing studies examining antihistamine effects.
  • Analysis of performance impairment data across various validated and unvalidated tests.

Main Results:

  • Consistent data suggest first-generation antihistamines impair performance.

Related Experiment Videos

  • A notable difference exists between older sedating and newer nonsedating antihistamines.

    • Conclusions:

    • First-generation antihistamines demonstrably cause performance deficits.
    • Second-generation antihistamines represent a safer alternative with reduced impairment.