Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

APC mutations in synovial sarcoma.

Tsuyoshi Saito1, Yoshinao Oda, Akio Sakamoto

  • 1Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

The Journal of Pathology
|March 29, 2002
PubMed
Summary

APC gene mutations are found in synovial sarcoma, correlating with beta-catenin accumulation. These APC mutations, unlike beta-catenin mutations, were observed in long-term survivors of this cancer.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association of Frailty with Improvement of Daily Activities and Health-related Quality of Life in Patients with Lumbar Spinal Stenosis Following Decompression Surgery.

American journal of physical medicine & rehabilitation·2026
Same author

Clinical Utility of <sup>68</sup>Ga-DOTATOC Positron Emission Tomography/Computed Tomography in Evaluating Metastatic Lesions of Clear Cell Renal Cell Carcinoma: A Case Report.

IJU case reports·2026
Same author

Rapid immunohistochemistry for intraoperative differentiation between high-grade gliomas and primary central nervous system lymphomas: a multicenter prospective study.

Brain tumor pathology·2026
Same author

Long-term clinical outcomes and recurrence factors in intracranial germinoma.

Journal of neuro-oncology·2026
Same author

Clinical Outcomes and Prognostic Factors in Patients With Pelvic Sarcomas.

Anticancer research·2026
Same author

Local bicarbonate ringer's therapy after resection of idiopathic solitary tumoural calcinosis.

Journal of surgical case reports·2026

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Accumulated beta-catenin acts as an oncoprotein in synovial sarcoma, linked to poor survival.
  • Beta-catenin mutations are infrequent in synovial sarcoma (8.2%).

Purpose of the Study:

  • To investigate genetic alterations in the APC gene's mutation cluster region (MCR) in synovial sarcoma.
  • To determine the frequency and characteristics of APC mutations in synovial sarcoma.

Main Methods:

  • Screening of 49 synovial sarcoma cases for APC gene mutations in the MCR.
  • Utilizing Single-Strand Conformation Polymorphism (SSCP) analysis and direct DNA sequencing.

Main Results:

  • Identified five missense APC mutations in four synovial sarcoma cases (8.2% frequency).

Related Experiment Videos

  • Mutations occurred at codons 1299, 1412, 1414, and a double mutation at codons 1398 and 1413.
  • One case also presented a beta-catenin mutation at codon 32.
  • All four cases with APC mutations were monophasic fibrous type and showed beta-catenin accumulation.
  • Three cases with APC mutations with follow-up data were long survivors.

    • Conclusions:

    • APC mutations occur in synovial sarcoma, representing a novel finding in sarcoma genetics.
    • APC mutations in synovial sarcoma are associated with beta-catenin accumulation and potentially favorable long-term outcomes.