Related Experiment Video

Updated: Oct 2, 2026

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus
10:49

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus

Published on: January 28, 2019

Incidence and prevalence of human group C rotavirus infections in Argentina

Alejandro A Castello1, Marcelo H Argüelles, Guillermo A Villegas

  • 1Laboratorio de Virología, Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes, Buenos Aires, Argentina.

Journal of Medical Virology
|March 29, 2002
PubMed

Insights

Human group C rotavirus infections are common in Argentine children, typically occurring later than group A infections. This study highlights their prevalence despite low detection rates in acute diarrhea cases.

Area of Science:

  • Virology
  • Pediatrics
  • Epidemiology

Background:

  • Human rotaviruses are a leading cause of severe diarrheal disease in children worldwide.
  • Group A rotavirus is the most common cause of rotavirus gastroenteritis, but other groups, including C, also cause human infections.
  • Understanding the epidemiology of different rotavirus groups is crucial for public health interventions.

Purpose of the Study:

  • To evaluate the incidence and characteristics of human group C rotavirus infections in children with acute diarrhea in Buenos Aires.
  • To assess previous exposure to group C rotavirus in the healthy population.
  • To compare the age distribution of group C rotavirus infections with group A rotavirus infections.

Main Methods:

  • Enzyme-linked immunosorbent assays (ELISA) using recombinant group C VP6 protein were employed to detect group C rotavirus in stool samples.
  • RT-PCR for VP6 and VP7 genes and antibody absorption tests confirmed positive cases.
  • Serum IgG antibodies were measured by ELISA and Western blot to assess previous exposure.

Main Results:

  • Only 1.02% of 976 stool samples from children with acute diarrhea tested positive for group C rotavirus.
  • The average age of children with group C rotavirus infection (5.86 years) was significantly higher than those with group A infection (1.63 years).
  • Serological analysis revealed that 50.3% of 844 healthy individuals had group C rotavirus-specific IgG antibodies, indicating frequent past infections.

Conclusions:

  • Group C rotavirus infections in Argentine children occur later in life compared to group A rotavirus.
  • Despite low detection rates in acute diarrhea, group C rotavirus infections are relatively common in children.
  • Group C rotavirus infections are frequent in older children (3-5 years) compared to infants (6-18 months), who are more affected by group A infections.

More Related Videos

Generation of Recombinant Arenavirus for Vaccine Development in FDA-Approved Vero Cells10:03

Generation of Recombinant Arenavirus for Vaccine Development in FDA-Approved Vero Cells

Published on: August 1, 2013

Related Concept Videos

Poliomyelitis01:17

Poliomyelitis

Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...
Cholera01:25

Cholera

Cholera is an acute gastrointestinal disease caused by the Gram-negative bacterium Vibrio cholerae. It is transmitted primarily via the fecal-oral route through the ingestion of contaminated water or food.Vibrio cholerae is a motile, Gram-negative bacterium of the family Vibrionaceae, primarily associated with waterborne outbreaks in areas with inadequate sanitation. Although over 200 serogroups of V. cholerae exist, only O1 and O139 are responsible for epidemic cholera. The O1 serogroup,...
Giardiasis01:12

Giardiasis

Giardiasis is a globally prevalent intestinal infection caused by the protozoan parasite Giardia duodenalis (also known as G. lamblia or G. intestinalis). This flagellated protozoan is the most frequently identified intestinal parasite in the United States and worldwide. Transmission primarily occurs via the fecal-oral route, with infection arising from ingestion of water or food contaminated with cysts. Individuals in low-resource settings, international travelers, outdoor enthusiasts, daycare...
Infectious Diseases and Their Occurrence01:28

Infectious Diseases and Their Occurrence

Infectious diseases appear in populations through various transmission patterns, influenced by pathogen characteristics, population immunity, environmental conditions, and social behavior. Understanding these patterns is essential for effective public health surveillance and intervention. These categories—sporadic, outbreak, epidemic, pandemic, and endemic—help frame the nature and scope of disease events.Sporadic diseases occur irregularly and infrequently, without a predictable temporal or...
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...