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Acquired factor VIII inhibitor treated with cyclophosphamide, vincristine, and prednisone
Eric C-Y Lian1, Mary Jo Villar, Lionel I Noy
1Division of Hematology/Oncology, University of Miami School of Medicine/Sylvester Cancer Center/Veterans Affairs Medical Center, Miami, Florida 33136, USA. elian@med.miami.edu
Abstract:
Life-threatening bleeding can occur in non-hemophiliacs with factor VIII inhibitor and is difficult to control. Various methods have been used to suppress the inhibitor. Since 1993 we treated 6 non-hemophilic patients with factor VIII inhibitor with cyclophosphamide, vincristine, and prednisone (CVP) every 3-4 weeks. Five had complete response with disappearance of factor VIII inhibitor and normalization of factor VIII after 1 to 7 cycles of CVP. One patient did not respond after 4 cycles of CVP; mitoxantrone was added to additional two cycles of CVP, and the inhibitor disappeared.