Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Age-related disability in multiple sclerosis.

Maria Trojano1, Maria Liguori, Giovanni Bosco Zimatore

  • 1Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy. mtrojano@neurol.uniba.it

Annals of Neurology
|March 29, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Profiling the long-term risk of severe adverse events in a cohort of multiple sclerosis patients treated with different treatment sequences: Results from the Italian Multiple Sclerosis and Related Disorders Registry (I-MS&RD) (ProSA study).

Multiple sclerosis (Houndmills, Basingstoke, England)·2026
Same author

Telemedicine for headache disorders in real-world practice: from patient experience to health system impact.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2026
Same author

Predictive factors of response to anti-CGRP pathway drugs in people with multiple sclerosis.

The journal of headache and pain·2026
Same author

Moral decision-making in real and sacrificial contexts: a pilot study on social cognition in mild cognitive impairment.

BMC psychology·2026
Same author

Longitudinal Transcriptomic Analysis Reveals Systemic Effects of Risdiplam in Adults with Spinal Muscular Atrophy.

Brain sciences·2026
Same author

Multidomain Fatigue, Cognitive, and Quality of Life Observations in Generalized Myasthenia Gravis Under Ravulizumab: A Case Series.

Neurology and therapy·2026

Age significantly impacts multiple sclerosis disability progression. Older patients experience faster disease advancement, suggesting age-adjusted metrics are crucial for understanding multiple sclerosis severity.

Area of Science:

  • Neurology
  • Clinical Research

Background:

  • The clinical course of multiple sclerosis (MS) is recognized as potentially age-related.
  • Understanding age's influence on MS progression is vital for patient management and research.

Purpose of the Study:

  • To investigate the relationship between age and the rate of disability progression in a large cohort of multiple sclerosis patients.
  • To determine how age at onset and current age affect disease severity and progression speed.

Main Methods:

  • Analysis of a hospital-based cohort of 1,463 definite multiple sclerosis cases.
  • Longitudinal follow-up (11,387.8 person-years) with regular Expanded Disability Status Scale (EDSS) assessments.
  • Application of an extended Kaplan-Meier method and regression models incorporating age as a covariate.

Related Experiment Videos

Main Results:

  • Expanded Disability Status Scale (EDSS) scores significantly correlated with current age and disease duration.
  • Patients aged 20-35 years had significantly longer median times to reach EDSS 4.0 and 6.0 compared to older age groups.
  • Current age (59% of model variability) had a greater impact on disease severity than age at onset, with a multiplicative effect observed when both were considered.

Conclusions:

  • Age is a significant determinant of the rate of disability progression in multiple sclerosis.
  • A faster rate of disease progression is observed in older patients, influenced by both age at onset and current age.
  • An age-adjusted progression index may offer a more accurate way to differentiate between multiple sclerosis patient groups.