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Related Experiment Videos

LPL polymorphism predicts stroke risk in men.

Alanna C Morrison1, Christie M Ballantyne, Molly Bray

  • 1Human Genetics Center, University of Texas-Houston Health Science Center, Houston, Texas 77030, USA.

Genetic Epidemiology
|March 29, 2002
PubMed
Summary
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The LPL S447X gene variant is linked to increased risk of stroke in men. This association appears independent of lipid levels and other common stroke risk factors.

Area of Science:

  • Genetics
  • Neurology
  • Cardiovascular Disease

Background:

  • Lipid level variations are linked to atherosclerotic vascular disease, including stroke.
  • Genes influencing lipid metabolism may impact stroke risk through direct or indirect pathways.

Purpose of the Study:

  • To investigate the association between lipoprotein lipase (LPL) and apolipoprotein E (APOE) gene polymorphisms and subclinical and clinical stroke.
  • To determine if these genetic variations contribute to stroke etiology independently of lipid levels.

Main Methods:

  • Analysis of LPL and APOE gene polymorphisms in the Atherosclerosis Risk in Communities (ARIC) Study cohort.
  • Subclinical stroke assessed via cerebral magnetic resonance imaging (MRI).
  • Clinical ischemic stroke incidence tracked over 7.5 years.

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Main Results:

  • LPL S291 and APOE genotypes showed no significant association with stroke.
  • LPL X447 genotypes were significantly associated with both subclinical and clinical stroke in men.
  • The association of LPL X447 with stroke risk was independent of lipid levels and other stroke risk factors.

Conclusions:

  • The LPL S447X polymorphism is a significant risk factor for subclinical cerebral infarction and clinical ischemic stroke in men.
  • This genetic risk appears to operate through mechanisms independent of lipid profiles and common stroke risk factors.