Related Experiment Videos
Crystallization-induced diastereoselection: asymmetric synthesis of substance P inhibitors
Philip J Pye1, Kai Rossen, Steven A Weissman
1Department of Process Research, Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, USA. philip_pye@merck.com
Chemistry (Weinheim an Der Bergstrasse, Germany)
|March 29, 2002
Abstract:
A novel three-component condensation followed by a crystallization-induced asymmetric transformation is used to build this key substance P inhibitor intermediate in a short synthetic sequence.