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Experience with ampicillin/sulbactam in severe infections

G Kanra1

  • 1Department of Pediatric Infectious Diseases, Hacettepe University School of Medicine, Ankara, Turkey. gkanra@gen.hun.edu.tr

The Journal of International Medical Research
|March 30, 2002
PubMed

Insights

Ampicillin combined with sulbactam, including its oral form sultamicillin, effectively treats various pediatric infections. This antibiotic combination shows high efficacy and tolerability for bacterial infections, including serious ones like meningitis.

Area of Science:

  • Pharmacology and Infectious Diseases
  • Microbiology and Antibiotic Resistance

Background:

  • Beta-lactamase-mediated resistance necessitates the development of beta-lactamase inhibitors.
  • Ampicillin/sulbactam and sultamicillin address resistance to traditional beta-lactam antibiotics.

Purpose of the Study:

  • To evaluate the clinical efficacy and tolerability of ampicillin/sulbactam and sultamicillin in pediatric patients.
  • To assess the effectiveness against a broad spectrum of bacterial pathogens and infections.

Main Methods:

  • Review of in vitro activity against Gram-positive and Gram-negative pathogens (aerobic and anaerobic).
  • Analysis of clinical trial data for various pediatric infections and post-operative prophylaxis.

Main Results:

  • Ampicillin/sulbactam demonstrated in vitro activity against a wide range of bacteria.
  • Clinical trials confirmed efficacy in treating pediatric upper respiratory, abdominal, periorbital, and CNS infections.
  • Effective in preventing post-operative surgical infections in pediatric patients.

Conclusions:

  • Ampicillin/sulbactam and sultamicillin are effective therapeutic options for numerous pediatric infections.
  • The combination's favorable efficacy and tolerability profile support its use in managing severe pediatric infections.

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