Medical treatment of ectopic pregnancy using parental methotrexate

Between January and December 1999, we were able to diagnose five cases of unruptured ectopic pregnancy, using a transabdominal convex sector transducer. All the five patients presented with lower abdominal pains but were in stable clinical state. They were treated with two doses of 50mg methotrexate intravenously, 48 hours apart. Four of the patients had clinical, immunological, and sonographic evidence of resolution. The only failure was in the patient whose gestation sac was 4.8cm in its maximal diameter. She eventually had laparotomy and salpingectomy.