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Relation of lipid and lipoprotein(a) to ischaemic stroke
Handan Misirli1, Göksel Somay, Nilgün Ozbal
1Haydarpaşa Numune Educational and Research Hospital, Department of Neurology, Istanbul, Turkey. ecemisirli@yahoo.com
Insights
Lipid profiles and lipoprotein(a) showed no significant link to ischemic stroke risk. However, hypertension and diabetes mellitus were identified as key independent risk factors for stroke.
Area of Science:
- Cardiovascular Medicine
- Neurology
- Clinical Chemistry
Background:
- The association between lipid profiles, lipoprotein(a) [Lp(a)], and ischemic stroke remains unclear.
- Understanding these relationships is crucial for identifying stroke risk factors.
Purpose of the Study:
- To investigate the correlation between lipid profiles, Lp(a), and vascular risk factors in ischemic stroke patients compared to a control group.
- To determine if lipids and Lp(a) are associated with specific stroke subtypes and carotid atherosclerosis.
Main Methods:
- Analysis of lipid profiles (total cholesterol, HDL-C, LDL-C, triglycerides) and Lp(a) in 79 ischemic stroke patients and 30 controls.
- Vascular risk factors, doppler ultrasonography for carotid atherosclerosis, and stroke subtypes were recorded.
- Statistical analysis including correlation and odds ratio calculations.
Main Results:
- No significant differences in total cholesterol, triglycerides, HDL-C, LDL-C, or Lp(a) were found between stroke patients and controls.
- Hypertension (OR=4.50) and diabetes mellitus (OR=4.43) were identified as significant independent risk factors for ischemic stroke.
- Elevated total cholesterol and Lp(a) levels were significantly associated with marked carotid stenosis detected by doppler ultrasonography.
Conclusions:
- Lipids and Lp(a) were not found to be independent risk factors for atherotrombotic and lacunar stroke subtypes.
- Hypertension and diabetes mellitus are confirmed as significant independent risk factors for ischemic stroke.
- Lp(a) concentration and carotid atherosclerosis show a significant association, suggesting a potential role in stroke pathogenesis.
Abstract:
The relationship of lipids and Lp(a) to ischemic stroke hasn't been established yet. Our aim was to determine lipid profile and vascular risk factors in stroke patients and compare them with control subjects. Seventy-nine consecutive patients with ischemic stroke were analyzed by total cholesterol, HDL-C, LDL-C, triglyceride, Lp(a) and doppler ultrasonography and vascular risk factors were recorded. Thirty control subjects of same ages were compared with the patient group. Lp(a) and lipids were correlated with stroke subtype and carotid atherosclerosis. There was no statistical significance between patients and control subjects related to total cholesterol, triglyceride, HDL-C, LDL-C and Lp(a) (P>0.05). Atherotrombotic and lacunar strokes didn't show any difference correlated with lipids and Lp(a). Hypertension and diabetes mellitus were important risk factors with (OR=4.50, 95% CI=1.25-16.22) and (OR=4.43, 95% CI=1.79-10.93) respectively. These results were statistically significant (P<0.05). Total cholesterol (308.67+/-85.82) and Lp(a) (32.10+/-17.30) values showed statistical significance (P<0.05) in patients with marked stenosis when compared with patients of normal doppler ultrasonography. Hypertension and diabetes mellitus were found as independent risk factors for ischemic stroke. Lipids and Lp(a) were not independent for atherotrombotic and lacunar stroke. Lp(a) concentration and carotid atherosclerosis in ultrasonography were associated significantly.