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Quantitation of Endothelial Cell Adhesiveness In Vitro
10:24

Quantitation of Endothelial Cell Adhesiveness In Vitro

Published on: June 18, 2015

Elevated soluble CD40 ligand is related to the endothelial adhesion molecules in patients with acute coronary

Dao-Quan Peng1, Shui-Ping Zhao, Yi-Fu Li

  • 1Department of Cardiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China. pengdq@hotmail.com

Clinica Chimica Acta; International Journal of Clinical Chemistry
|March 30, 2002
PubMed

Insights

Soluble CD40 ligand (sCD40L) levels are elevated in acute coronary syndrome, correlating with adhesion molecules and negatively with HDL-C. This suggests CD40L’s role in atherosclerosis pathogenesis.

Area of Science:

  • Cardiovascular Biology
  • Immunology
  • Biochemistry

Background:

  • The CD40-CD40L pathway is implicated in atherosclerosis inflammation.
  • Vascular adhesion molecules are key markers and contributors to atherosclerotic plaque vulnerability.
  • Inflammation-driven plaque instability can lead to acute coronary events like myocardial infarction.

Purpose of the Study:

  • To investigate soluble CD40 ligand (sCD40L) levels in different coronary heart disease subtypes.
  • To examine the relationship between sCD40L and vascular adhesion molecules (sICAM-1, sVCAM-1).

Main Methods:

  • Enzyme-linked Immunosorbent Assay (EIA) was employed.
  • Serum concentrations of sCD40L, sICAM-1, and sVCAM-1 were measured.
  • Comparisons were made between patients with acute coronary syndrome, stable coronary heart disease, and controls.

Main Results:

  • sCD40L levels were significantly higher in acute coronary syndrome patients compared to controls and stable coronary heart disease patients.
  • sCD40L showed a positive correlation with sICAM-1, triglycerides, and apoB.
  • sCD40L demonstrated a negative correlation with HDL-cholesterol.

Conclusions:

  • Elevated sCD40L in acute coronary syndrome suggests its involvement in the disease's pathogenesis.
  • Serum CD40L concentration is positively associated with adhesion molecules.
  • CD40L levels are inversely related to serum high-density lipoprotein cholesterol (HDL-C).
Abstract

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