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Metadoxine in acute alcohol intoxication: a double-blind, randomized, placebo-controlled study
Leonid S Shpilenya1, Alexander P Muzychenko, Giovanni Gasbarrini
1Narcological County Dispensary, Vasyleostrovsky District 4.th, Line V. 0.2 3-2 5, St. Petersburg, Russia.
Alcoholism, Clinical and Experimental Research
|March 30, 2002
Summary
Metadoxine (pyridoxol L-2-pyrrolidone-5-carboxylate) significantly speeds up ethanol elimination in acute alcohol intoxication. This leads to faster recovery and reduced toxic symptoms, suggesting its potential as a treatment.
Area of Science:
- Pharmacology
- Toxicology
- Clinical Medicine
Background:
- Preliminary clinical results suggest metadoxine efficacy in acute alcohol intoxication.
- Further investigation is needed to confirm its effectiveness.
Purpose of the Study:
- To investigate the effectiveness of metadoxine in managing acute ethanol intoxication.
Main Methods:
- A double-blind, randomized, multicenter, placebo-controlled trial.
- 58 patients with acute ethanol intoxication received either 900-mg intravenous metadoxine or placebo.
- Clinical and biochemical evaluations were performed at multiple time points post-treatment.
Main Results:
- Metadoxine significantly decreased ethanol half-life (p < 0.013) and accelerated elimination.
- Median time to recovery from intoxication was reduced (0.95 hr with metadoxine vs. 2.34 hr with placebo; p = 0.013).
- Metadoxine treatment led to a significant improvement in toxic symptomatology compared to placebo (p < 0.002).
Conclusions:
- Metadoxine accelerates ethanol elimination and hastens recovery from acute intoxication.
- It also improves behavioral toxic symptoms associated with ethanol consumption.
- Metadoxine shows promise as a therapeutic agent for acute ethanol intoxication.