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Updated: Aug 2, 2026
08:53
Safety Precautions and Operating Procedures in an (A)BSL-4 Laboratory: 2. General Practices
Published on: October 3, 2016
Damage control: a guide to dealing with an infectious break
1Taconic Anmed, 7642 Standish Place, Rockville MD 20855, USA. twoweis@erols.com
Lab Animal
|March 30, 2002
Summary
Maintaining microbial stability in laboratory animals is crucial for research integrity. This study outlines a strategic sequence for managing infectious outbreaks, from detection to resolution.
Area of Science:
- Veterinary Medicine
- Laboratory Animal Science
- Research Management
Background:
- Microbial status disruptions in laboratory animals can significantly impede research continuity.
- Maintaining a controlled environment is essential for reproducible scientific outcomes.
- Infectious breaks pose a substantial risk to research integrity and animal welfare.
Purpose of the Study:
- To propose a structured approach for managing microbial status changes in research animal facilities.
- To detail a sequence of actions for investigating and controlling infectious outbreaks.
- To minimize research disruptions caused by microbial contamination events.
Main Methods:
- Review of established protocols for managing infectious disease outbreaks in animal facilities.
- Development of a sequential framework for response and control.
- Case study analysis of potential infectious "break" scenarios.
Main Results:
- A defined sequence of events for addressing microbial status changes was identified.
- The framework covers detection, investigation, source identification, and control measures.
- Proactive management strategies can mitigate research impact.
Conclusions:
- A systematic approach to managing infectious breaks is vital for research continuity.
- Effective investigation and control protocols are necessary to maintain animal model integrity.
- Implementing a clear response sequence enhances laboratory animal facility management.
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