[Genetics of human narcolepsy]
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Updated: Oct 1, 2026

Noninvasive, High-throughput Determination of Sleep Duration in Rodents
Published on: April 18, 2018
Y Dauvilliers1, M Tafti, M Billiard
1Service de Neurologie B, 80, avenue Augustin Fliche, Hôpital Gui-de-Chauliac, 34295 Montpellier, France.
Abstract:
Narcolepsy is known to be a complex disorder; both genetic and environmental factors play a role in its pathophysiology. Although narcolepsy presents one of the tightest association with a specific HLA antigen (DQB1*0602), there is strong evidence that non-HLA genes also confer susceptibility, both monoaminergic and hypocretinergic systems seem to be involved and may interfere with the phenotype. Implication of the hypocretin system is well-established in both canine and murine narcolepsy (caused by mutation) and a consistent reduction in hypocretin neuron seems to be the cause of human narcolepsy. An autoimmune process is probable.
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