[Integrative study of bronchial asthma in perimenopausal women]

The paper presents results of complex study of the specific features of the course of bronchial asthma (BA) in the peri- and early postmenopausal periods, including investigations of hormonal and immunological statuses, bone tissue mineral density and blood lipids, and evaluates the effects of peri- and early postmenopause and climacteric syndrome of varying severities on the course of BA. A drug test using estrogens has been developed to evaluate their effects on bronchial airflow. It has been shown that estrogens do not negatively affect bronchial airflow in most patients with BA in the peri- and early postmenopausal periods. The efficiency of replacement hormone therapy with estrogen-progestogen drugs has been for the first time estimated in these patients. Treatment with the estrogen-progestogen drug clinonorm increases the effects of endogenous cortisol, which makes it possible to reduce a dosage of glucocorticosteroids and to increase the mineral density of bone tissue.